Getting My ceesdekker To Work
Getting My ceesdekker To Work
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Using one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our exploration passions include:
It had been only in the 1990s nevertheless, when nanotechnology had State-of-the-art to some amount in which one molecules might be manipulated, that the main experimental units commenced to appear.
[Laughs] ‘It had been undoubtedly a fantastic threat! At time, I was well aware that it could go wrong and that I could become significantly less thriving, but I just overlooked that. Curiosity has constantly been my strongest driving power. And fortuitously it all labored out.’
Deposition and atomic pressure microscopy of particular person phthalocyanine polymers involving nanofabricated electrodes
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Microbiology has only existed for your century, since we began to study micro-organisms more significantly. I believed nanobiology was an ideal expression, for the reason that all molecular Organic applicable interactions occur within the nanoscale: a protein is a few nanometres in size, DNA is 2 nm thick.’
‘To start with we checked out biological techniques that has a Actual physical see and acted on The idea from the equipment we realized. It took a number of years prior to we commenced Doing the job much more on the large biological difficulties. I then began to call it nanobiology, a term that did not exist at time.
Researching DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.
The rotors harness Power from the nanoscale drinking water and ion flow that may be produced by a static chemical or electrochemical possible gradient during the nanopore, which might be proven through a salt gradient or utilized voltage, respectively. These artificial nanoengines self-Arrange and operate autonomously in physiological disorders, suggesting strategies to constructing Electricity-transducing motors at nanoscale interfaces.
It was throughout this period that Dekker completed investigation on magnetic ceesdekker.net spin devices and on sounds in superconductors and semiconductors.
Testing pseudotopological and nontopological types for SMC-pushed DNA loop extrusion against roadblock-traversal experiments
Nature Physics many thanks the nameless reviewers for their contribution to the peer critique of this work.
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2013, controlled shaping of live bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations in the handedness of histone tetrasomes